The Future of
in vitro SKIN
development,
now.
Technical, scientific and marketing innovation within your company’s reach.
Born from the passion of a group of scientists from USP and UNIFESP for skin biology, tissue engineering and clinical research, SKIN4LAB has the highest scientific excellence , combined with ethical and innovation standards.
All this technical-academic knowledge is now at the service of human and animal health and well-being, ensuring the most modern and safe treatment and care for skin-related problems, through its reproduction in the laboratory.
Due to its expertise, SKIN4LAB also makes this knowledge available to companies in various segments, through technical-scientific consultancy that provides comprehensive support for the development of projects, from the conception of the idea and the feasibility of its execution to obtaining the final product.
products
Highly similar epidermal and dermo-epidermal equivalents.
Through exclusive, personalized and biologically complex models, SKIN4LAB produces epidermal and dermo-epidermal equivalents with high similarity to natural skin, which can be used in a wide range of applications, from cosmetic and dermatological product testing to safety assessment for physical, chemical and biological genotoxic agents.
Normal human epidermal and dermo-epidermal equivalents
Unaltered skin to be used for general testing.
Human epidermal and dermal-epidermal equivalents of different phototypes
Normal in vitro skin with the presence of pigmentation, indicated for evaluating products with UV protection, whitening agents and cosmetics.
Aged human epidermal and dermo-epidermal equivalents
In vitro skin that reproduces the natural aging process, developed especially for evaluating and testing anti-aging products.
Customized human epidermal and dermo-epidermal equivalents
Personalized in vitro skin expressing distinct target genes for evaluation of specific genetic profiles and/or altered physiology.
R&D
Research and Development
SKIN4LAB has a multidisciplinary team of scientists and project managers with extensive academic and market experience. Their in-depth knowledge of skin physiology and tissue engineering enables SKIN4LAB to collaborate and provide comprehensive support to basic and applied scientific research projects.
Through specialized monitoring and guidance, SKIN4LAB guarantees full satisfaction of the needs of each project, from understanding the objectives to the desired results , proposing successful strategies through innovative methodologies and meticulous attention to details.
For these reasons, SKIN4LAB is today a strategic partner for professionals, academic institutions and companies from different segments.
TrichoSkin Equivalent
Model with hair follicle cells.
PetSkin Equivalent
Canine oral mucosa model.
Human epidermal and dermo-epidermal equivalents for grafts
Skin for burn grafting developed using patient-derived cells.
Human epidermal and dermal-epidermal equivalents – HPV
In vitro skin that reproduces changes caused by the Human Papillomavirus (HPV) of high and low oncogenic risk.
Applications
Safety and efficacy testing for medicines and cosmetics;
Quantitative and semi-quantitative safety and permeation tests for physical, chemical and biological genotoxic agents, such as solar and ionizing radiation, fertilizers, herbicides, pesticides, environmental degradation products, pollutants, organic waste, prebiotics, probiotics, postbiotics, food, cigarette smoke, among others;
Tests for the veterinary industry;
Analysis of the immunological profile and oxidative stress mediators;
Image analysis for the study of skin morphology, pathophysiology and space interactions.
Analysis of cell proliferation, differentiation and death, oxidative damage, production of inflammatory mediators, among others;
Preclinical and screening tests of potential drugs for the treatment of different skin diseases, such as those affecting pigmentation (e.g. vitiligo), dermatitis, psoriasis, diabetes, warts associated with HPV, among other conditions;
Multiomics analysis.
FAQ
What is an in vitro skin model?
They are models derived from human or animal skin cells, developed in the laboratory and which reproduce the complexity of the skin with high precision.
How are in vitro skin models developed?
Skin-derived cells are grown in the laboratory under conditions that allow them to organize three-dimensionally, reproducing the structure of the skin.
For which markets are in vitro skin models indicated?
In vitro skin models offer a promising alternative for innovation, research and development in different markets such as medicines, cosmetics, new bioactives and natural products, agriculture, fertilizers, tobacco, food, veterinary medicine, waste, among others.
How much does it cost to develop in vitro skin models?
The cost will depend on each project. However, considering that cultured cells proliferate very efficiently in the laboratory, it is possible to obtain a much larger quantity of skin using this system when compared to skin fragments obtained from samples derived from surgical procedures. In this way, it is possible to obtain skin at a reduced cost.
What technical and ethical standards does SKIN4LAB observe in its work?
SKIN4LAB follows the Guidance Document on Good in vitro Method Practices (GIVIMP) (OECD 286, 2018), as well as the guides for carrying out specific tests approved by the OECD, BraCVAM, ICCVAM, EURL ECVAM, JaCVAM, among other agencies that validate alternative methods to replace animal testing.
How important are in vitro skin models?
The importance of these models goes far beyond their potential to replace animal testing, but also lies in their ability to increase the speed, accuracy and relevance of research results, reduce the risk of inaccurate results and ensure greater reliability in predicting responses in humans and animals, at competitive costs.
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